A wealth of information on antibiotic resistance caused by methylation of rRNA has been revealed during the last ten years. Modifications at eight 23S rRNA ...
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One of the major resistance mechanisms is caused by the members of the Erm methyltransferase family, which modify the single 23S rRNA nucleotide A2058 ( ...
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Jan 11, 2022 · The paper addresses an important unresolved mechanism of antibiotic resistance caused by a RNA-modifying enzyme Cfr, a protein that confers ...
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Jul 1, 2006 · A novel multidrug resistance phenotype mediated by the Cfr rRNA methyltransferase is observed in Staphylococcus aureus and Escherichia coli.
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Oct 10, 2019 · Abstract. Pathogens often receive antibiotic resistance genes through horizontal gene transfer from bacteria that produce natural antibiotics.
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Abstract. Methylation of 16S ribosomal RNA (rRNA) has recently emerged as a new mechanism of resistance against aminoglycosides among gram-negative pathoge.
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Methylation of nucleobases at select positions of rRNA is one of the classical hallmarks of antibiotic resistance. The resistance-conferring methyltransferases ...
Dec 18, 2020 · This modification sterically blocks binding of several classes of antibiotics to 23S rRNA, resulting in a multidrug-resistant phenotype in ...
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Due to the posttranslational methylation of the A site of 16S rRNA at position A1408, NpmA leads to pan-aminoglycoside resistance encompassing both 4,5- and 4,6 ...
Mar 1, 2023 · Prevalence of acquired antibiotic-resistance rRNA methyltransferases. Resistance-conferring rRNA methyltransferase genes are named based on ...
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